Methyl Tetrahydrofolate Reductase (MTHFR)
Methyl Tetrahydrofolate Reductase
- MTHFR is a common genetic defect said to be present in up to 40% of the population.
- The result is what is known as a methylation defect which can cause reduced liver function (for example, from 50 -70% of what is normal for you) and many other problems which can dramatically affect your health.
- There are many different variations of the defect but the two most common variants for the gene are C677T and A1298C.
- These are the ones most often tested for in pathology laboratories.
- The 677 is more associated with a greater risk of increased homocysteine levels which can result in a higher risk of heart disease, cardiovascular problems, stroke, increased pain and inflammation and chemical sensitivity
- The 1298 is more associated with miscarriage, depression, hypertension, delayed speech, muscle pain, insomnia, irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, hand tremor, memory loss, headaches, and brain fog.
- This test can be performed on either a blood specimen or saliva.